The Surgeon
Volume 10, Issue 1 , Pages 25-32 , February 2012

The management of soft tissue sarcomas

  • Steven Cutts

      Affiliations

    • James Paget University Hospital, Lowestoft Road, Gorleston, Great Yarmouth, Norfolk NR31 6LA, United Kingdom
    • Corresponding Author InformationCorresponding author. 11 Fern Drive, Cringleford, Norwich, Norfolk NR4 7JT, United Kingdom. Tel.: +44 07798 863416; fax: +44 01493 452 066.
    • ,
  • Ferrero Andrea

      Affiliations

    • James Paget University Hospital, Lowestoft Road, Gorleston, Great Yarmouth, Norfolk NR31 6LA, United Kingdom
    • ,
  • Raimondo Piana

      Affiliations

    • Orthopaedic Oncology Unit, CTO Hospital, Turin, Italy
    • ,
  • Richard Haywood

      Affiliations

    • Norfolk and Norwich Hospital, Colney Ln, Norwich, Norfolk NR4 7UY, United Kingdom

Received 21 July 2011 ,Accepted 25 September 2011.

References 

  1. Grimer R, Judson I, Peake D, Seddon B. Guidelines for the management of soft tissue sarcomas. Sarcoma. 2010;2010(506182):15
  2. NICE Improving Outcomes Guidelines for soft tissue sarcoma. Cancer service guidance CSG Sarcoma. Issued: March 2006.
  3. Hoos A, Lewis JJ, Brennan MF. Soft tissue sarcoma: prognostic factors and multimodal treatment. Chirurg. 2000 Jul;71(7):787–794
  4. Westbury G. The management of soft tissue sarcoma. JBJS. 1989;71-B:2–3
  5. In:  Fletcher CDM,  Unni KK,  Mertens F editor. World Health Organization classification of tumours pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002;
  6. Rasmussen SA, Friedman JM. NF1 gene and neurofibromatosis 1. Am J Epidemiol. 2000;151(No. 1):33–40
  7. Chen CS, Suthers G, Carroll J, Rudzki Z, Muecke J. Sarcoma and familial retinoblastoma. Clin Experiment Ophthalmol. 2003;31(5):392–396
  8. Bell DW, Varley JM, Szydlo TE, et al. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science. 1999;286(No. 5449):2528–2531
  9. Visuri T, Pulkkinen P, Paavolainen P. Malignant tumors at the site of total hip prosthesis. Analytic review of 46 cases. Arthroplasty. 2006 Apr;21(3):311–323
  10. Keel SB, Jaffe KA, Petur Nielsen G, Rosenberg AE. Orthopaedic implant-related sarcoma: a study of twelve cases. Mod Pathol. 2001 Oct;14(10):969–977
  11. Johnson G, Smith G, Dramis A, Grimer R. Why do patients with soft tissue sarcoma present so late?. JBJS. 2006;88-B(Supp. II):293
  12. Johnson CJ, Pynsent PB, Grimer RJ. Clinical features of soft tissue sarcomas. Ann R Coll Surg Engl. 2001 May;83(3):203–205
  13. Knapp EL, Kransdorf MJ, Letson GD. Diagnostic imaging update: soft tissue sarcomas. Cancer Control. 2005 Jan–Feb;12(1):22–26
  14. Datir A, James SL, Ali K, Lee J, Ahmad M, Saifuddin A. MRI of soft-tissue masses: the relationship between lesion size, depth, and diagnosis. Clin Radiol. 2008 Apr;63(4):373–378discussion 379–380. Epub 2007 Dec 21
  15. Soler R, Castro JM, Rodríguez E. Value of MR findings in predicting the nature of the soft tissue lesions: benign, malignant or undetermined lesion?. Comput Med Imaging Graph. 1996 May–Jun;20(3):163–169
  16. Tiessen L, Grimer RJ, Davies AM, Carter SR, Abudu A, Tilman RM. A cost effective strategy for staging soft tissue sarcomas. British Orthopaedic Oncology Society. JBJS. 2006;88-B(Supp. II):293
  17. Trojani M, Contesso G, Coindre JM, et al. Soft tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer. 1984;33:37–42
  18. Simon MA, Enneking WF. Management of soft-tissue sarcomas of the extremities. J Bone Joint Surg Am. 1976 Apr;58(3):317–327
  19. McKee MD, Liu DF, Brooks JJ, et al. The prognostic significance of margins width for extremity and trunk sarcoma. J Surg Oncol. 2004;85:68–76
  20. Pitcher ME, Fish S, Thomas JM. Management of soft tissue sarcoma. Br J Surf. 1994;81:1136–1139
  21. Rosenberg SA, Tepper J, Gladstein E. The treatment of soft tissue sarcoma of the extremities. Prospective randomized evaluation (1) limb sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg. 1982;196:305–315
  22. Clark MA, Thomas JM. Amputation for soft tissue sarcoma. Lancet Oncol. 2003;4:335–342
  23. Bickels J, Wittig JC, Kollender Y, et al. Sciatic nerve resection: is that truly an indication for amputation?. Clin Orthop. 2002;399:201–204
  24. Gadd MA, Casper ES, Woodruff JM, McCormack PM, Brennan MF. Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma. Ann Surg. 1993 Dec;218(6):703–704
  25. Murata H, Kalra S, Ahrens H, Abudu A, Grimer RJ, Carter SR, et al. Soft tissue sarcomas of the pelvis. JBJS. 2008;90-B(Supp. II):401
  26. Pradhan A, Cheung YC, Grimer RJ, Peake D, Al-Muderis OA, Thomas JM, et al. Soft tissue sarcomas of the hand. Oncological outcome and prognostic factors. JBJS. Feb 2008;90-B(No 2):
  27. Storm FK, Mahvu DM. Diagnosis and management of retroperitoneal soft tissue sarcoma. Ann Surg. July 1991;214(No 1):2–7
  28. Liberman B, Riad S, Griffin B, O’Sullivan B, Catton CN, Blackstein ME, et al. Lymph node metastasis in soft tissue sarcoma of the extremeties. JBJS. 2008;90-B(Supp. I):87
  29. Barwick WJ, Goldberg JA, Scully , et al. Vascularised tissue transfers to adjuvant radiation therapy in primary soft tissue sarcoma of the extremity. Int J Radiat Oncol Biol Phys. 2003;56:1112–1116
  30. Suit HD, Mankin HJ, Wood WC, et al. Treatment of the patient with stage M0 soft tissue sarcoma. J Clin Oncol. 1988;6:854–862
  31. Barkley HT, Martin RG, Romsdahl MM, et al. Treatment of soft tissue sarcomas by preoperative irradiation and conservative surgical resection. Int J Radiat Oncol Biol Phys. 1998;42:563–572
  32. O’Sullivan B, David AM, Turcotte R, et al. Preoperative versus post operative radiotherapy in soft tissue sarcoma of limbs: a randomized trial. Lancet. 2002;359:2235–2241
  33. Davis AM, O’Sullivan B, Bell RS, et al. Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in the treatment of soft tissue sarcomas. Clin Orthop. 2002;397:177–189
  34. Willet CG, Czito BG, Tyler DS. Intra-operative radiation therapy. J Clin Oncol. 2007;25:971–977
  35. Tierney JF, Mosseri V, Stewart LA, et al. Adjuvant chemotherapy for soft tissue sarcoma: review and meta-analysis of the published results of randomised clinical trials. Br J Cancer. 1995;72:469–475
  36. Gortzak E, Azzarelli A, Buesa J, et al. A randomised phase II study of neo adjuvant chemotherapy for high risk adult soft tissue sarcoma. Eur J Cancer. 2001;37:1096–1103
  37. Lewis JJ, Leung D, Heslin M, et al. Association of local recurrence with subsequent survival in extremity soft tissue sarcoma. J Clin Oncol. 1997;15:646–652
  38. Pisters PWT, O’Sullivan B, Maki RG. Evidence based recommendations for local therapy for soft tissue sarcomas. Review. J Clin Oncol. March 10, 2007;25(8):1003–1008
  39. Coindre P, Terrier NB, Bui F, Bonichon F, Collin V, Le Doussal AM, et al Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J Clin Oncol. 1996;14:869–877
  40. Steward WP, Verweij J, Somers R, et al. Granulocyte-macrophage colony stimulating factor allows safe escalation of dose intensity of chemotherapy in metastatic adult soft tissue sarcomas: a study of the European Organisation for research and treatment of cancer soft tissue and bone sarcoma group. J Clin Oncol. 1993;11:15–21
  41. Gustafson P. Soft tissue sarcoma. Epidemiology and prognosis in 508 patients. Acta Orthop Scand Suppl. 1994 Jun;259:1–31
  42. Frustaci S, et al. Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial. J Clin Oncol. 2001;19(5):1238–1247
  43. Dhaliwal J, Grimer RJ, Carter SR, Tillman RM, Abudu A. Outcome following local recurrence of soft tissue sarcoma. JBJS. 2005;88-B(Supp. II):298–299
  44. Catton CN, O’Sullivan B, Kotwall C, Cummings B, Hao Y, Fornasier V. Outcome and prognosis in retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 1994 Jul 30;29(5):1005–1010
  45. Youssef E, Fontanesi J, Mott M, Kraut M, Lucas D, Mekhael H, et al. Long-term outcome of combined modality therapy in retroperitoneal and deep-trunk soft-tissue sarcoma: analysis of prognostic factors. Int J Radiat Oncol Biol Phys. 2002 Oct 1;54(2):514–519
  46. Osseous invasion by soft tissue sarcoma is rare at 9%. Elias DA, White LM, Simpson DJ, Kandel RA, Tomlinson G, Bell RS, et al. Osseous invasion by soft tissue sarcoma: assessment with MR imaging. Radiology. 2003;
  47. Vezeridis MP, Moore R, Karakousis CP. Metastatic patterns in soft tissue sarcomas. Arch Surg. 1983;118:119–918

PII: S1479-666X(11)00129-6

doi: 10.1016/j.surge.2011.09.006

The Surgeon
Volume 10, Issue 1 , Pages 25-32 , February 2012

Article Tools

* Image Usage & Resolution