The Surgeon
Volume 8, Issue 5 , Pages 262-266 , October 2010

Up-regulation of signal transducer and activator of transcription-3 is associated with aggravation of ulcerative colitis

  • Fujun LI

      Affiliations

    • Department of digestion in Xiangya Hospital of Central South University, Changsha, Hunan, PR China
    • Corresponding Author InformationCorresponding author. Tel./fax: +86 731 84327106.
    • ,
  • Yiyou ZOU

      Affiliations

    • Department of digestion in Xiangya Hospital of Central South University, Changsha, Hunan, PR China
    • ,
  • Xuefeng LI

      Affiliations

    • Department of digestion in 2nd Xiangya Hospital of Central South University, Changsha, Hunan, PR China

Received 4 March 2010 ,Accepted 28 March 2010.

References 

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  15. Takahashi T, Abe H, Arai H. Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis. J Biol Chem. 2005;280:7100–7106
  16. O’shea JJ. Targeting the Jak/STAT pathway for immunosuppression. Ann Rheum Dis. 2004;63(Suppl 2):ii67–ii71
  17. HAN Xiaonan, SOSNOWSKA Danuta, Bonkowski Erin l, Denson Lee a. Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis. Gastroenterology. 2005;129:185–203
  18. Bai AP, Hu PJ, Chen J, Song X, Chen W, Peng WX, et al. Blockade of STAT3 by antisense oligonucleotide in TNBS-induced murine colitis. Int J Colorectal Dis. 2007;22:625–635

PII: S1479-666X(10)00124-1

doi: 10.1016/j.surge.2010.03.003

The Surgeon
Volume 8, Issue 5 , Pages 262-266 , October 2010

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