The Surgeon
Volume 8, Issue 2 , Pages 111-116 , April 2010

The effects of smoking on fracture healing

  • A. Sloan

      Affiliations

    • Faculty of Health, Life and Social Sciences, University of Lincoln, Brayford Pool, Lincoln, Lincolnshire LN6 7TS, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 1522 886458.
    • ,
  • I. Hussain

      Affiliations

    • Faculty of Health, Life and Social Sciences, University of Lincoln, Brayford Pool, Lincoln, Lincolnshire LN6 7TS, UK
    • ,
  • M. Maqsood

      Affiliations

    • Research and Development Department, United Lincolnshire Hospitals NHS Trust, Lincoln County Hospital, Greetwell Road, Lincoln, Lincolnshire LN2 5QY, UK
    • ,
  • O. Eremin

      Affiliations

    • Research and Development Department, United Lincolnshire Hospitals NHS Trust, Lincoln County Hospital, Greetwell Road, Lincoln, Lincolnshire LN2 5QY, UK
    • ,
  • M. El-Sheemy

      Affiliations

    • Faculty of Health, Life and Social Sciences, University of Lincoln, Brayford Pool, Lincoln, Lincolnshire LN6 7TS, UK
    • Research and Development Department, United Lincolnshire Hospitals NHS Trust, Lincoln County Hospital, Greetwell Road, Lincoln, Lincolnshire LN2 5QY, UK

Received 15 October 2009 ,Accepted 22 October 2009.

References 

  1. Wipfli H, Samet JM. Global economic and health benefits of tobacco control: part 1. Clin Pharmacol Ther. 2009 Jun 17;
  2. Gruer L, Hart CL, Gordon DS, Watt GC. Effect of tobacco smoking on survival of men and women by social position: a 28 year cohort study. BMJ. 2009;338:b480
  3. Porter SE, Hanley EN. The musculoskeletal effects of smoking. J Am Acad Orthop Surg. 2001 Jan–Feb;9(1):9–17
  4. Bartecchi CE, MacKenzie TD, Schrier RW. The human costs of tobacco use (1). N Engl J Med. 1994 Mar 31;330(13):907–912
  5. Capewell S, Hayes DK, Ford ES, Critchley JA, Croft JB, Greenlund KJ, et al. Life-years gained among US adults from modern treatments and changes in the prevalence of 6 coronary heart disease risk factors between 1980 and 2000. Am J Epidemiol. 2009 Jun 18;
  6. Rees TD, Liverett DM, Guy CL. The effect of cigarette smoking on skin-flap survival in the face lift patient. Plast Reconstr Surg. 1984 Jun;73(6):911–915
  7. Riefkohl R, Wolfe JA, Cox EB, McCarty KS. Association between cutaneous occlusive vascular disease, cigarette smoking, and skin slough after rhytidectomy. Plast Reconstr Surg. 1986 Apr;77(4):592–595
  8. Kroll SS. Necrosis of abdominoplasty and other secondary flaps after TRAM flap breast reconstruction. Plast Reconstr Surg. 1994 Oct;94(5):637–643
  9. Bailey MH, Smith JW, Casas L, Johnson P, Serra E, de la Fuente R, et al. Immediate breast reconstruction: reducing the risks. Plast Reconstr Surg. 1989 May;83(5):845–851
  10. Hartrampf CR, Bennett GK. Autogenous tissue reconstruction in the mastectomy patient. A critical review of 300 patients. Ann Surg. 1987 May;205(5):508–519
  11. Mosely LH, Finseth F. Cigarette smoking: impairment of digital blood flow and wound healing in the hand. Hand. 1977 Jun;9(2):97–101
  12. Pitts KR, Yoon Y, Krueger EW, McNiven MA. The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol Biol Cell. 1999 Dec;10(12):4403–4417
  13. Netscher DT, Clamon J. Smoking: adverse effects on outcomes for plastic surgical patients. Plast Surg Nurs. 1994 Winter;14(4):205–210
  14. Nolan J, Jenkins RA, Kurihara K, Schultz RC. The acute effects of cigarette smoke exposure on experimental skin flaps. Plast Reconstr Surg. 1985 Apr;75(4):544–551
  15. Czernin J, Waldherr C. Cigarette smoking and coronary blood flow. Prog Cardiovasc Dis. 2003 Mar–Apr;45(5):395–404
  16. Frances C, Boisnic S, Hartmann DJ, Dautzenberg B, Branchet MC, Charpentier YL, et al. Changes in the elastic tissue of the non-sun-exposed skin of cigarette smokers. Br J Dermatol. 1991 Jul;125(1):43–47
  17. Akoz T, Akan M, Yildirim S. If you continue to smoke, we may have a problem: smoking's effects on plastic surgery. Aesthetic Plast Surg. 2002 Nov–Dec;26(6):477–482
  18. Sorensen LT, Friis E, Jorgensen T, Vennits B, Andersen BR, Rasmussen GI, et al. Smoking is a risk factor for recurrence of groin hernia. World J Surg. 2002 Apr;26(4):397–400
  19. Siana JE, Rex S, Gottrup F. The effect of cigarette smoking on wound healing. Scand J Plast Reconstr Surg Hand Surg. 1989;23(3):207–209
  20. Wong LS, Martins-Green M. Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing. Wound Repair Regen. 2004 Jul–Aug;12(4):471–484
  21. Oe K, Miwa M, Sakai Y, Lee SY, Kuroda R, Kurosaka M. An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity. J Bone Joint Surg Br. 2007 Jan;89(1):133–138
  22. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol. 2003 Jul;200(4):500–503
  23. Pryor WA. Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity. Environ Health Perspect. 1997 Jun;105(Suppl. 4):875–882
  24. Comhair SA, Erzurum SC. Antioxidant responses to oxidant-mediated lung diseases. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L246–L255
  25. Sherwin MA, Gastwirth CM. Detrimental effects of cigarette smoking on lower extremity wound healing. J Foot Surg. 1990 Jan–Feb;29(1):84–87
  26. Toyooka T, Ibuki Y. Cigarette sidestream smoke induces phosphorylated histone H2AX. Mutat Res. 2009 May 31;676(1–2):34–40
  27. Hoffmann D, Hoffmann I. The changing cigarette, 1950–1995. J Toxicol Environ Health. 1997 Mar;50(4):307–364
  28. Zevin S, Gourlay SG, Benowitz NL. Clinical pharmacology of nicotine. Clin Dermatol. 1998 Sep–Oct;16(5):557–564
  29. Hukkanen J, Jacob P, Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev. 2005 Mar;57(1):79–115
  30. Cobb TK, Gabrielsen TA, Campbell DC, Wallrichs SL, Ilstrup DM. Cigarette smoking and nonunion after ankle arthrodesis. Foot Ankle Int. 1994 Feb;15(2):64–67
  31. Lefkowitz RJ. Editorial: smoking, catecholamines, and the heart. N Engl J Med. 1976 Sep 9;295(11):615–616
  32. Waeber B, Schaller MD, Nussberger J, Bussien JP, Hofbauer KG, Brunner HR. Skin blood flow reduction induced by cigarette smoking: role of vasopressin. Am J Phys. 1984 Dec;247(6 Pt 2):H895–H901
  33. Winniford MD, Wheelan KR, Kremers MS, Ugolini V, van den Berg E, Niggemann EH, et al. Smoking-induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alterations in coronary artery tone. Circulation. 1986 Apr;73(4):662–667
  34. Bornmyr S, Svensson H. Thermography and laser-Doppler flowmetry for monitoring changes in finger skin blood flow upon cigarette smoking. Clin Physiol. 1991 Mar;11(2):135–141
  35. van Adrichem LN, Hovius SE, van Strik R, van der Meulen JC. Acute effects of cigarette smoking on microcirculation of the thumb. Br J Plast Surg. 1992 Jan;45(1):9–11
  36. Folsom AR. Epidemiology of fibrinogen. Eur Heart J. 1995 Mar;16(Suppl. A):21–23discussion 3–4
  37. El-Zayadi AR, Selim O, Hamdy H, El-Tawil A, Moustafa H. Heavy cigarette smoking induces hypoxic polycythemia (erythrocytosis) and hyperuricemia in chronic hepatitis C patients with reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy. Am J Gastroenterol. 2002 May;97(5):1264–1265
  38. Seyler LE, Pomerleau OF, Fertig JB, Hunt D, Parker K. Pituitary hormone response to cigarette smoking. Pharmacol Biochem Behav. 1986 Jan;24(1):159–162
  39. Seyler LE, Fertig J, Pomerleau O, Hunt D, Parker K. The effects of smoking on ACTH and cortisol secretion. Life Sci. 1984 Jan 2;34(1):57–65
  40. de Vernejoul MC, Bielakoff J, Herve M, Gueris J, Hott M, Modrowski D, et al. Evidence for defective osteoblastic function. A role for alcohol and tobacco consumption in osteoporosis in middle-aged men. Clin Orthop Relat Res. 1983 Oct;(179):107–115
  41. Fang MA, Frost PJ, Iida-Klein A, Hahn TJ. Effects of nicotine on cellular function in UMR 106-01 osteoblast-like cells. Bone. 1991;12(4):283–286
  42. Krupski WC. The peripheral vascular consequences of smoking. Ann Vasc Surg. 1991 May;5(3):291–304
  43. Jorgensen LN, Kallehave F, Christensen E, Siana JE, Gottrup F. Less collagen production in smokers. Surgery. 1998 Apr;123(4):450–455
  44. Leow YH, Maibach HI. Cigarette smoking, cutaneous vasculature, and tissue oxygen. Clin Dermatol. 1998 Sep–Oct;16(5):579–584
  45. Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 2005 May 24;111(20):2684–2698
  46. Sorensen LT, Jorgensen S, Petersen LJ, Hemmingsen U, Bulow J, Loft S, et al. Acute effects of nicotine and smoking on blood flow, tissue oxygen, and aerobe metabolism of the skin and subcutis. J Surg Res. 2009 Apr;152(2):224–230
  47. Smirnova E, Shurland DL, Ryazantsev SN, van der Bliek AM. A human dynamin-related protein controls the distribution of mitochondria. J Cell Biol. 1998 Oct 19;143(2):351–358
  48. Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F, et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell. 2001 Oct;1(4):515–525
  49. Li Y, Dowbenko D, Lasky LA. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem. 2002 Mar 29;277(13):11352–11361
  50. Helt CE, Rancourt RC, Staversky RJ, O'Reilly MA. p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity. Toxicol Sci. 2001 Oct;63(2):214–222
  51. Whyte DA, Broton CE, Shillitoe EJ. The unexplained survival of cells in oral cancer: what is the role of p53?. J Oral Pathol Med. 2002 Mar;31(3):125–133
  52. Hollenbeck PJ. The pattern and mechanism of mitochondrial transport in axons. Front Biosci. 1996 Jul 1;1:d91–102
  53. Nicotine Whiteford L. CO and HCN: the detrimental effects of smoking on wound healing. Br J Community Nurs. 2003 Dec;8(12):S22–S26
  54. Gaston MS, Simpson AH. Inhibition of fracture healing. J Bone Joint Surg Br. 2007 Dec;89(12):1553–1560
  55. Wright VJ. Osteoporosis in men. J Am Acad Orthop Surg. 2006 Jun;14(6):347–353
  56. Baron JA. Smoking and estrogen-related disease. Am J Epidemiol. 1984 Jan;119(1):9–22
  57. Lam LT. Distractions and the risk of car crash injury: the effect of drivers' age. J Safety Res. 2002 Fall;33(3):411–419
  58. Wen CP, Tsai SP, Cheng TY, Chan HT, Chung WS, Chen CJ. Excess injury mortality among smokers: a neglected tobacco hazard. Tob Control. 2005 Jun;14(Suppl. 1):i28–i32
  59. Nelson HD, Nevitt MC, Scott JC, Stone KL, Cummings SR. Smoking, alcohol, and neuromuscular and physical function of older women. Study of Osteoporotic Fractures Research Group. JAMA. 1994 Dec 21;272(23):1825–1831
  60. Sacks JJ, Nelson DE. Smoking and injuries: an overview. Prev Med. 1994 Jul;23(4):515–520
  61. Kyro A, Usenius JP, Aarnio M, Kunnamo I, Avikainen V. Are smokers a risk group for delayed healing of tibial shaft fractures?. Ann Chir Gynaecol. 1993;82(4):254–262
  62. Brown CW, Orme TJ, Richardson HD. The rate of pseudarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study. Spine. 1986 Nov;11(9):942–943
  63. Silcox DH, Daftari T, Boden SD, Schimandle JH, Hutton WC, Whitesides TE. The effect of nicotine on spinal fusion. Spine. 1995 Jul 15;20(14):1549–1553
  64. Whitesides TE, Hanley EN, Fellrath RF. Smoking abstinence. Is it necessary before spinal fusion?. Spine. 1994 Sep 1;19(17):2012–2014
  65. Carpenter CT, Dietz JW, Leung KY, Hanscom DA, Wagner TA. Repair of a pseudarthrosis of the lumbar spine. A functional outcome study. J Bone Joint Surg Am. 1996 May;78(5):712–720
  66. Adams CI, Keating JF, Court-Brown CM. Cigarette smoking and open tibial fractures. Injury. 2001 Jan;32(1):61–65
  67. van Adrichem LN, Hovius SE, van Strik R, van der Meulen JC. The acute effect of cigarette smoking on the microcirculation of a replanted digit. J Hand Surg [Am]. 1992 Mar;17(2):230–234
  68. Gullihorn L, Karpman R, Lippiello L. Differential effects of nicotine and smoke condensate on bone cell metabolic activity. J Orthop Trauma. 2005 Jan;19(1):17–22
  69. Skott M, Andreassen TT, Ulrich-Vinther M, Chen X, Keyler DE, LeSage MG, et al. Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats. J Orthop Res. 2006 Jul;24(7):1472–1479
  70. Raikin SM, Landsman JC, Alexander VA, Froimson MI, Plaxton NA. Effect of nicotine on the rate and strength of long bone fracture healing. Clin Orthop Relat Res. 1998 Aug;(353):231–237
  71. Shapiro F. Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cell Mater. 2008;15:53–76
  72. Campanile G, Hautmann G, Lotti T. Cigarette smoking, wound healing, and face-lift. Clin Dermatol. 1998 Sep–Oct;16(5):575–578
  73. Abidi NA, Dhawan S, Gruen GS, Vogt MT, Conti SF. Wound-healing risk factors after open reduction and internal fixation of calcaneal fractures. Foot Ankle Int. 1998 Dec;19(12):856–861
  74. Lind J, Kramhoft M, Bodtker S. The influence of smoking on complications after primary amputations of the lower extremity. Clin Orthop Relat Res. 1991 Jun;(267):211–217

PII: S1479-666X(09)00015-8

doi: 10.1016/j.surge.2009.10.014

The Surgeon
Volume 8, Issue 2 , Pages 111-116 , April 2010

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