Elsevier

The Surgeon

Volume 1, Issue 2, April 2003, Pages 63-75
The Surgeon

Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I)

https://doi.org/10.1016/S1479-666X(03)80118-XGet rights and content

Gut-associated lymphoid tissue (GALT) is the largest lymphoid organ in the body. This is not surprising considering the huge load of antigens (Ags) from food and commensal bacteria with which it interacts on a daily basis. Gut-associated lymphoid tissue has to recognise and allow the transfer of beneficial Ags whilst concurrently dealing with and successfully removing putative and overtly harmful Ags. This distinctive biological feature of GALT is believed to be crucial to good health. Deregulation or dysfunction of GALT is thought to predispose to inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. The exact mechanism(s) underlying the pathogenesis of IBD is (are) poorly understood and the immunological defects in GALT are poorly documented. Advances in immunology have highlighted the importance of dendritic cells (DCs), which are the key Ag presenting cells in tissues and lymphoid compartments. Their crucial role in GALT, in health and disease is discussed in this review. Interaction of DCs with T cells in the gut produces a subset of T lymphocytes, which have immunosuppressive function. Inappropriate Ag uptake and presentation to naïve T cells in mesenteric lymph nodes may lead to T cell tolerance in GALT. These various complex factors in the gut are discussed and their possible relevance to IBD evaluated

References (130)

  • CA Janeway

    Approaching the asymptote? Evolution and revolution in immunology

  • B Osborne et al.

    Notch and the immune system

    Immunity

    (1999)
  • S Artavanis-Tsakonas et al.

    Notch signaling: cell fate control and signal integration in development

    Science

    (1999)
  • M Boirivant et al.

    Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis

    J Clin Invest

    (1996)
  • M Cella et al.

    Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

    J Exp Med

    (1996)
  • A Nakao et al.

    Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

    Nature

    (1997)
  • A Sambuelli et al.

    Serum transforming growth factor-betal levels increase in response to successful anti-inflammatory therapy in ulcerative colitis

    Aliment Pharmacol Ther

    (2000)
  • D Seegert et al.

    Increased expression of IL-16 in inflammatory bowel disease

    Gut

    (2001)
  • L Mayer

    Mucosal immunity and gastrointestinal antigen processing

    J Pediatr Gastroenterol Nutr

    (2000)
  • K Bjerke et al.

    T cell distribution is different in follicle-associated epithelium of human Peyer's patches and villous epithelium

    Clin Exp Immunol

    (1988)
  • RL Owen et al.

    M cell transport of Vibrio cholerae from the intestinal lumen into Peyer's patches: a mechanism for antigen sampling and for microbial transepithelial migration

    J Infect Dis

    (1986)
  • KL Cepek et al.

    Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells

    J Immunol

    (1993)
  • G Janossy et al.

    Human T lymphocytes of inducer and suppressor type occupy different microenvironments

    Nature

    (1980)
  • WS Selby et al.

    Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques

    Gut

    (1984)
  • A Jarry et al.

    Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3- lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

    Eur J Immunol

    (1990)
  • LK Trejdosiewicz et al.

    Expression of T-cell receptors TcRl (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa

    Immunology

    (1989)
  • M Budhraja et al.

    Duodenal mucosal T cell subpopulation and bacterial cultures in acquired immune deficiency syndrome

    Am J Gastroenterol

    (1987)
  • G Janossy et al.

    The tissue distribution of T lymphocytes expressing different CD45 polypeptides

    Immunology

    (1989)
  • PR Streeter et al.

    A tissue-specific endothelial cell molecule involved in lymphocyte homing

    Nature

    (1988)
  • M Nakache et al.

    The mucosal vascular addressin is a tissue-specific endothelial cell adhesion molecule for circulating lymphocytes

    Nature

    (1989)
  • M Briskin et al.

    Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue

    Am J Pathol

    (1997)
  • MB Williams et al.

    Homing of naive and memory T lymphocyte subsets to Peyer's patches, lymph nodes, and spleen

    J Immunol

    (1997)
  • AJ Stagg et al.

    Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin

    Eur J Immunol

    (2002)
  • A Hamann et al.

    Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo

    J Immunol

    (1994)
  • D Picarella et al.

    Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells

    J Immunol

    (1997)
  • S Arihiro et al.

    Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease

    Pathol Int

    (2002)
  • KL Cepek et al.

    Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin

    Nature

    (1994)
  • MP Schon et al.

    Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice

    J Immunol

    (1999)
  • C Folwaczny et al.

    Antinuclear autoantibodies in patients with inflammatory bowel disease. High prevalence in first-degree relatives

    Dig Dis Sci

    (1997)
  • L Mayer et al.

    Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease

    J Clin Invest

    (1990)
  • A Rudolphi et al.

    Polyclonal expansion of adoptively transferred CD4+ alpha beta T cells in the colonic lamina propria of scid mice with colitis

    Eur J Immunol

    (1996)
  • MH Claesson et al.

    CD4+ T lymphocytes injected into severe combined immunodeficient (SCID) mice lead to an inflammatory and lethal bowel disease

    Clin Exp Immunol

    (1996)
  • MJ Palmen et al.

    CD4+ T cells from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rodents migrate to the recipient's colon upon transfer; down-regulation by CD8+ T cells

    Clin Exp Immunol

    (1998)
  • O Cohavy et al.

    Colonic bacteria express an ulcerative colitis pANCA-related protein epitope

    Infect Immun

    (2000)
  • P Rutgeerts et al.

    Clinical value of the detection of antibodies in the serum for diagnosis and treatment of inflammatory bowel disease

    Gastroenterology

    (1998)
  • WJ Sandbom et al.

    Association of antineutrophil cytoplasmic antibodies with resistance to treatment of left-sided ulcerative colitis: results of a pilot study

    Mayo Clin Proc

    (1996)
  • CL Sutton et al.

    Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease

    Gut

    (2000)
  • B Sendid et al.

    Anti-Saccharomyces cerevisiae mannan antibodies in familial Crohn's disease

    Am J Gastroenterol

    (1998)
  • J Banchereau et al.

    Dendritic cells and the control of immunity

    Nature

    (1998)
  • D Bell et al.

    Dendritic cells

    Adv Immunol

    (1999)
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